Department of Respiratory Medicine, Taihe Hospital Affiliated to Hubei University of Medicine, China
Research Article
Exploring the Mechanism of Feilike Capsule in the Treatment of Chronic Obstructive Pulmonary Disease Based on Network Pharmacology, Transcriptomics and Molecular Docking Technology
Author(s): Xiong Chen*, Conghui Wang, Huai Zhang, Dong Yang, Long Pan, Jin Xie, Yanhui Zhou, Qiang Sun, Junti LU, Lizhi Zhou, Xi Wang, Hongmei Chen, Lizhu LIU and Chunqi Ai
To explore the molecular mechanism of Chronic Obstructive Pulmonary Disease (COPD) based on network pharmacology, transcriptomics and molecular docking technology. Databases including TCMSP, SwissTarget Prediction, OMIM, Gene Cards, Drug bank, String, Metascape were used to search the active components and target proteins of feilike capsule, the target proteins shared with COPD were screened out, and the information of signal pathways and biological functions involved by these target proteins were obtained. 114 active ingredients of Feilike Capsule were obtained, including 214 potential targets for treating COPD. The protein interaction network was obtained through String database and Cytoscape software, and 14 potential core targets were obtained by network topology analysis, which were AKT1, TNF, SRC, MMP9, PTGS2, CASP3, EGFR, TP53, STAT3, MAPK3, GAPDH, MAPK1, IL2 and STAT1. Go functio.. View More»
