Department of Pharmaceutical Chemistry and Drug Technology, North-Caucasus Federal University, Stavropol, Russia
Research Article
Coagulation Activity of Human Blood Plasma in the Presence of Ultrasound-Processed Fucoidan
Author(s): Victoria Suprunchuk*
Aim: To evaluate the effect of low-frequency ultrasound with variable parameters and environments on biological activity of fucoidan within determination of human plasma coagulation values.
Methods: The study was performed using fucoidan derived from the tangle Fucus vesiculosus. Fucoidan was processed with a high-intensity low-frequency ultrasound in water environment with and without administration of surface-active substances. The effectiveness and change in biological activity of the polysaccharide was evaluated using clotting tests: Prothrombin Test (PT test), partial thromboplastin test (APTT test), and Thrombin Test (TT test).
Results: During this study, it was determined that fucoidan can extend the clotting time of human plasma in vitro both before and after ultrasound processing. Higher values we.. View More»
