Abstract

VALPROIC ACID-INDUCED THROMBOCYTOPENIA: A LONGITUDINAL STUDY

Author(s): Manoj Kumar Sahu1, Surbhi Dubey2

BACKGROUND
Valproate shows the most promising efficiency in treating mood as well as anxiety disorders; however, thrombocytopenia is one of the most common side effects associated with it. The perceived novelty and under recognition of the platelet lowering effects of valproate is illustrated by various case reports of thrombocytopenia associated with valproate in psychiatric populations.
AIMS
Present study aims is to investigate the relationship between platelet count & VPA therapy, age, and duration of medication.
SETTINGS AND DESIGN
It was a longitudinal observational study conducted at Department of Psychiatry, Pt. JNM Medical College, Raipur.
METHODS AND MATERIAL
The sample consisted of patients of either sex, aged between 18 to 65 years who were prescribed valproate therapy by the treating doctor. Patients were evaluated at baseline, at every month up to three months and at six months. The platelet counts were determined using an automatic haematology analyser.
STATISTICAL ANALYSIS
Correlation statistics were used to analyse the collected data.
CONCLUSION Most of the time thrombocytopenia is mild and transient which resolves spontaneously. Regular monitoring of platelet level is required in the high risk groups.