Author(s): Ravish H1 , Mohan Kumar R 2
BACKGROUND Diabetes Complications is one of the major long-term complications of diabetes mellitus. Previous studies have proved that Type 2 Diabetes is frequently associated with an inflammatory status with increased levels of serum hsCRP, an inflammatory marker, but little information is available on the relationship between low-grade inflammation and diabetic early complications. OBJECTIVES 1. To determine the serum level of hsCRP in Type-2 Pre diabetics patients with and without early diabetic complications and to compare with that of normal subjects. 2. To study the association of serum hsCRP levels with glycosylated haemoglobin and AC ratio. METHODOLOGY 56 Type 2 Pre Diabetic patients in the age range of 50-60 years with >10years of duration of diabetes were recruited. Diabetic patients were divided into 2 groups, diabetic patients with AC ratio between 30-300 mg/gm and diabetic patients with AC ratio >300mg/gm. 24age and sex matched normal subjects were recruited for this study. Serum hsCRP levels were measured by turbidometry method. RESULTS There was a significant increase in serum hsCRP levels in both the diabetic groups (mean=4.77±3.95) compared to normal controls (mean=2.35±2.64). The hsCRP levels showed a positive correlation with HbA1c (r =0.38, p=0.007) and AC ratio (r= 0.33, p=0.01) in diabetic patients. CONCLUSION Serum hsCRP is increased in prediabetes patients and correlates with HbA1c and albuminuria. Thus, estimation of serum hsCRP levels helps in early intervention and prevention of further complications in diabetic prediabetes patients.