Anil Kumar Sharma1, Azmatulla Shaik2, G. Chitti Babu3, Khizer Hussain Afroze M4, Praveen Agarwal5
INTRODUCTION
The process of inflammation is one of the most fundamental responses of the vascularised living tissue to local injury.1 Inflammation is a universal host defense process involving a complex network of cell-cell, cell-mediator & tissue interactions.2
AIM AND OBJECTIVES
To study of anti-inflammatory effect of calcium channel blockers in rat paw edema model.
MATERIALS AND METHODS
To evaluate the anti-inflammatory effect with different doses of calcium channel blockers nifedipine, verapamil and standard drug ibuprofen in experimentally induced acute model of inflammation in male Wister rat. Inter drug comparison of anti-inflammatory efficacy of nifedipine, verapamil with standard drug ibuprofen in rats. Divide the animals into 3 groups each comprising at least six rats. Control group inject saline, standard group inject ibuprofen 20 mg/kg. test group inject (nifedipine & verapamil) subcutaneously. After 30 min inject 0.1ml 1% (w/v) Carrageenin in the plantar region of the left paw of all rats. The left hind paw was measured plethysmograph, immediately (zero hour) and 4 hours after the sub plantar injection of Carrageenin. The difference between zero hour volume and the paw volume recorded at the end of 4 hrs. Indicated the actual volume.
RESULT
The statistical test ANOVA is applied to inter drug comparison. It is found that drug. Nifedipine 1mg/kg (86%) has more efficacy significantly as compared to standard drug Ibuprofen 20mg/kg (55%), and drug Verapamil 1mg/kg (71%) for its anti-inflammatory action. (F value is 94.27 >tab F 5.82) so this method is statistically highly significant.
CONCLUSION
Thus it was found that nifedipine has better anti-inflammatory efficacy as compared to ibuprofen, verapamil in various experimental anti-inflammatory models. The various experimental anti-inflammatory models were rat paw edema method. The calcium channel blockers included were nifedipine, verapamil and standard drug ibuprofen. Nifedipine has anti-inflammatory effect in acute inflammation, verapamil possess anti-inflammatory effect only in acute inflammation. But on inter drug comparison nifedipine has better anti-inflammatory efficacy than ibuprofen &verapamil on rat paw edema method. Thus it was found that nifedipine has better anti-inflammatory efficacy as compared to ibuprofen, verapamil in various experimental anti-inflammatory models.
