Author(s): Sonica Sharma1

The adverse effects of ionic and nonionic contrast media, were compared in a group of 44 healthy renal donors undergoing renal angiography as a screening procedure, for adverse reactions and change in renal function. MATERIALS AND METHODS44 healthy renal donors, with normal renal function and no associated co-morbid conditions, who underwent renal angiography under DSA as a screening procedure for renal assessment were selected. Of them, 22 donors were randomly chosen to be given ionic contrast medium (Diatrizoate Sodium, Diatrizoate Meglumine) and 22 nonionic contrast medium (Iohexol and Iopamidol), in the dosage of 1 ml/kg body weight. They were assessed pre and 48 hours post procedure for vitals and laboratory assessment of blood (blood urea, serum creatinine), Urine (specific gravity, proteins, RBC etc.) and GFR by DTPA scan. RESULTSOnly mild type of adverse reactions like injection site pain, feeling of warmth and nausea were noted in both the groups. No adverse reactions of moderate or severe type were noted in either group. No significant change in the renal function was noted in both the groups as assessed by blood analysis (blood urea & Serum creatinine), urine analysis and GFR by DTPA scan 48 hours post contrast administration. CONCLUSIONThese results suggest that in dosage of 1ml/kg body weight, which is adequate for good opacification and necessary clinical information, ionic contrast media are as safe as more expensive nonionic media in healthy patients with no co-morbid conditions