Hirday Pal Singh Bhinder1, T. K. Kamble2, Sourya Acharya3
Metabolic syndrome, insulin resistance, prediabetes and Diabetes Mellitus (DM) type 2 are all associated to a more extensive and even premature atherosclerosis both in the coronary and the carotid arteries. They are all found to be associated with cardiovascular risk factors. Carotid Intima Media Thickness (CIMT) is considered surrogate marker of atherosclerosis, early and cheap method of detection of Cardiovascular Disease (CVD). It is necessary to assess CIMT in prediabetes for cardiovascular morbidity and mortality.
MATERIALS AND METHODS
This was a prospective case control study of carotid intima media thickness in prediabetes. A total of 100 patients of prediabetes and equal number of age and sex matched controls were enrolled. After detailed history and clinical examination, bilateral assessment of intima media thickness was done in common carotid artery. Statistical analysis was done by using descriptive and inferential statistics.
Mean value of CIMT for cases (0.79±0.06 mm) was higher than for controls (0.72±0.02 mm). The difference in the two groups was found to be statistically significant (P<0.05, S).
Mean CIMT was higher in prediabetes group in comparison to controls, however, was not in abnormal range. According to this model on multiple regression analysis among cases, serum Triglyceride (TG) and age were found to be responsible for increased CIMT.