D. Radha Krishnan1, G. Soumini2, M. G. V. Adithya3
Subclinical hypothyroidism is a biochemical diagnosis characterized by raised thyroid stimulating hormone (TSH) and normal free T3 & T4, without clinical features of hypothyroidism. Clinical significance of SCH remains uncertain and controversial. Symptoms of SCH may vary from being asymptomatic to having mild nonspecific symptoms. There are still controversies surrounding SCH and associated risk of various cardiovascular diseases (CVDs), pregnancy outcomes, neuropsychiatric issues, metabolic syndrome, and dyslipidemia. This review will summarize the current data related to the effects of SCH on cardiovascular risk, SCH in pregnancy, in dyslipedemia and clinical guidelines on management of this condition. The evidence has been updated by a Pub med search on the risks and treatment of subclinical hypothyroidism of most recent articles published until March 2015.