Abstract

STUDY OF NEURON SPECIFIC ENOLASE (NSE) IN PERINATAL ASPHYXIA & ITS ROLE AS AN EARLY MARKER OF BRAIN INJURY

Author(s): Manoj Narayan Paliwal1, Prachi Paliwal2, Meena Varma3, Mohammad Khaliq Shaikh4, Swati Mulye5

BACKGROUND
Perinatal asphyxia is a major cause of neurological morbidity in infants. Hypoxic ischaemic encephalopathy (HIE) after perinatal asphyxia is a condition in which serum concentration of Neuron specific enolase may be elevated. There are very few studies about its usefulness in asphyxiated newborns.
AIMS AND OBJECTIVES
To determine the serum levels of Neuron Specific Enolase (NSE) in newborns with perinatal asphyxia and its relation with different stages of hypoxic ischaemic encephalopathy.
METHODS
We have determined the serum levels of NSE by ELISA method in 100 asphyxiated newborns and 100 healthy newborns (control group). Blood samples were taken on day 1 and day 3 of life in all newborns.
RESULTS AND CONCLUSION
The mean serum values of NSE were found to be decreased on day 3 in asphyxiated neonates and negative correlation was seen between day 1 and day 3 for NSE.