Study of Histomorphological Spectrum of Mucinous Tumours of Ovary in a Tertiary Care Center in Thrissur, Kerala, India

Abstract

Bharathi Udhayakumar1, Lovely Jose2, Freena Rose3

BACKGROUND
Mucinous ovarian tumours have various histomorphological patterns.
Histopathological examination plays an important role in classifying ovarian
tumours for prognosis and better treatment. Mucinous ovarian tumours are
classified into benign cystadenomas, borderline mucinous tumours and malignant
mucinous cystadenocarcinomas. This study was done to evaluate the distribution
of ovarian tumours with respect to various parameters like age, laterality, size,
loculation, stratification of cells, nuclear atypia, to study the gross morphological
patterns of the various histopathological tumour types and evaluate the
association between various parameters of ovarian tumours and risk of
malignancy.
METHODS
A cross sectional study was conducted in the Department of Pathology, in a tertiary
health care centre over a period of 5 years. The study includes cases of mucinous
cystadenomas, borderline mucinous tumours and cystadenocarcinomas. Formalin
fixed and paraffin embedded sections were reviewed. Data was collected &
entered in Microsoft Office Excel 2007 sheet.
RESULTS
Among 32 cases of mucinous tumours studied 15 are mucinous cystadenomas, 10
are borderline tumours and 7 are cystadenocarcinomas. The mean age is 45 years.
1 case of mucinous cystadenocarcinoma showed bilateralism. 68.8 % of the
tumours were more than 15 cms in size. 72 % of the tumours were multiloculated
and 28 % were uniloculated. 78.1 % of the tumours have stratification of less than
4 cell-thickness. 46.9 % of tumours had no nuclear atypia, 31.2 % had mild atypia
and 21.9 had severe nuclear atypia.
CONCLUSIONS
Benign cystadenomas were more common than malignant and borderline tumours.
The mean age of presentation was 45 years.

image