Abstract

STUDY OF HEMATOLOGICAL PROFILE BEFORE DURING AFTER COMPLETION OF DOTS THERAPY IN PULMONARY TUBERCULOSIS

Author(s): Shidram Kamate1, B. Ramesh2, N. Bhaktavatchalam3

ABSTRACT: Tuberculosis (TB) is an infectious disease caused by the bacillus Mycobacterium tuberculosis. It typically affects the lungs (pulmonary TB) but can affect other sites as well (extra pulmonary TB). Pulmonary tuberculosis may produce reversible abnormalities of peripheral blood. TB can cause diverse laboratory abnormalities such as anemia, increased Erythrocyte, Sedimentation rate and thrombocytopenia. To study complete hematological parameters namely Hb%, total count, differential count, platelet count, reticulocyte count, ESR, peripheral smear. The aim of the present study is Comparison of hematological profile before, during and after completion of DOTS in pulmonary tuberculosis. 100 patients were included in the study with symptoms suggestive of TB in Dr. B. R. Ambedkar Medical College & Hospital, Bangalore from Oct 2011 to December 2012. The incidence of Tuberculosis infection was greater in males (70%) compared to females (30%). Anemia was present in 99% of cases, among which normocytic, normochromic in 84% cases followed by microcytic hypochromic in 11% cases. Most of the patients (92%) had total count more than 11,000. Among these 49%, had lymphocytopenia, 35% had neutrophilia, monocytosis in 38%, basophilia in 45% cases. 50% had normal platelets and 33% had thrombocytopenia. 100% had elevated ESR levels. In this study there is a significant post treatment changes in Hb, TC, Monocyte, Platelet count, ESR, RBC count. No significant post treatment changes in Lymphocyte, Neutrophill, Basophill, Eosinophill, Reticulocyte count. Hematological profile of patients improved during and after completion of Anti Tubercular treatment under DOTS.