Darshna Jain1, Manoj Narayan Paliwal2, Mohammad Khaliq Shaikh3, Shilpa Mittal4, Prachi Paliwal5, Deepasha Shahi Bagzai6
Glycated Haemoglobin (HbA1c) is the indicator of glycaemic status over long-term. Diabetes and obesity currently threaten the health, wellbeing and economic welfare of humanity. The study was designed to study the correlation between glycated hemoglobin and serum lipid profile in obese type 2 diabetic patients and obese non diabetic patients in Malwa region.
MATERIALS AND METHODS
This case control study comprised of a total of 200 obese (BMI ≥25 kg/m²) patients (148 males and 52 females) who visited the Outpatient Department of Sri Aurobindo Medical College and Postgraduate Institute, Indore. Out of which, those 100 obese patients with diabetes were taken as cases and 100 obese non-diabetic were taken as controls. Ethical clearance obtained for the study from the Institute Ethical Committee.
200 obese subjects included in the study out of which 148 (76%) were males and 52 (24%) were females. The majority (71%) of the cases had glycated haemoglobin value >9%, whereas majority (84%) of the control had glycated haemoglobin value in the range of 6-9%. A significant difference (P<0.0001) were found between the cases and controls. Glycated haemoglobin has a significant positive correlation with TC (total cholesterol), TG (triglycerides), LDL-C (low density lipoprotein), VLDL-C (very low density lipoprotein) whereas a significant negative correlation with HDL-C (high-density lipoprotein) and HDL-C /LDL-C ratio.
Our study ensures HbA1c status in obese diabetics and obese non-diabetics. HbA1c showed positive correlations with LDL-C cholesterol and negative correlations with HDL-C cholesterol and HDL-C/LDL-C ratio. A significant correlation exists between HbA1c and lipid profile. These findings suggest that HbA1c level can be used as good parameter for predicting the lipid profile. Glycated haemoglobin level can be used as an alarming factor for blood glucose dysregulation as well as lipid dysregulation in patients. The better the glycaemic control as reflected by HbA1c the better would be the lipidemic state. Achieving the target in HbA1c will contribute in improving the lipid state in patients.