STUDY OF CLINICAL, RADIOLOGICAL, BACTERIOLOGICAL SPECTRUM OF PULMONARY TUBERCULOSIS RELATION TO CD-4 CELL COUNTS IN PATIENTS WITH HIV INFECTION

Abstract

S. Subba Rao1, G. Aruna2, U. Kiran Kumar3

Pulmonary infections have diverse presentations in the HIV-seropositive patient, creating difficulty and delay in diagnosis and treatment. The chest radiographic appearances of patients presenting with pulmonary symptoms are frequently nonspecific. Further characterization of chest radiographic patterns in correlation with clinical findings and laboratory values would be helpful in narrowing the differential diagnosis of pulmonary disease in HIV-seropositive patients. The study of the clinical, radiological and bacteriological manifestations of pulmonary tuberculosis in relation to CD4 count in HIV infected patients helps in early detection and treatment of tuberculosis so that we can prevent the spread of tuberculosis.

MATERIAL AND METHOD: this is a Cross sectional study conducted at the department of Pulmonary Medicine, SVRR Government General Hospital, Tirupati during January 2011 To April 2012. Study sample being Total number of patients who attended Chest OP and were admitted in Pulmonary Medicine ward of SVRR Government General Hospital, Tirupati with Tuberculosis and HIV during the study period.

SUMMARY: Majority of patients were in the age group 30-40 years.Out of 115 people 72.17% were males 27.82% females.Most common presenting symptoms were cough (96%), fever (83%).Among x-ray findings Unilateral upperzone infiltrative lesions were more common than lower zone infiltrations in sputum positive patients.Sputum positivity was seen in 53.91% of patients.Mean CD4 count in this study was 177.08±155.47. Most of the patients (66.07%) had CD4 counts <200 cells/μl. 100% of military TB had CD4 <200 cells/μl.

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