Abstract

SERUM PARAOXONASE ACTIVITY IN RENAL TRANSPLANT RECIPIENTS

Author(s): Saritha Gadicherla1, Suma M. N2, Parveen Doddamani3

BACKGROUND
Serum paraoxonase is an enzyme synthesised in the liver. It is known to prevent atherosclerosis by inhibiting oxidation of low-density lipoprotein. Renal transplant recipients have increased tendency for developing atherosclerosis and cardiovascular disease. Reduced activity of serum paraoxonase contributes to accelerated atherosclerosis and increased cardiovascular complications in these patients.
The aim of this study was to estimate serum paraoxonase activity in renal transplant recipients and compare it with healthy controls.
MATERIALS AND METHODS
30 renal transplant recipients and 30 age and sex matched healthy controls were taken for the study. Serum paraoxonase activity, blood urea, serum creatinine and uric acid were estimated in these groups. The serum paraoxonase activity was correlated with urea, creatinine and uric acid levels.
RESULTS
Serum paraoxonase activity was reduced in renal transplant recipients compared to healthy controls. There was a negative correlation between paraoxonase activity and the levels of urea, creatinine and uric acid levels.
CONCLUSION
In this study, the paraoxonase activity was reduced in renal transplant recipients compared to controls. The increased cardiovascular disease in these patients could be due to reduced paraoxonase activity