Author(s): Vijayasamundeeswari Chinnathambipalayam Kandaswamy1, Sudha Rangasamy2, Sangeetha Panneerselvam3
Diabetes mellitus (DM) is a metabolic disorder characterised by chronic hyperglycemia resulting from deficiency of insulin or insulin resistance. Adenosine Deaminase [ADA] is an enzyme involved in purine nucleoside metabolism and plays a vital role in maintaining adenosine concentration. Oxidative stress gets more pronounced in chronic hyperglycemia which further increases ADA activity aggravating insulin resistance. Recently, growing evidence suggests an association of uric acid with diabetes mellitus. The current study is an attempt to assess ADA as a predictor of glycaemic status and to evaluate the role of serum uric acid levels in type 2 Diabetes mellitus [T2 DM].
AIM AND OBJECTIVES
To determine the activity of serum ADA and uric acid levels in type 2 diabetes patients and correlate them with HbA1c.
MATERIALS AND METHODS
A cross sectional study was done on 135 subjects and were divided into 3 groups. Group A: 45 normal healthy adults, Group B: 45 Type 2 Diabetes mellitus patients with HbA1c <7% and Group C: 45 Type 2 Diabetes mellitus patients with HbA1c >7%. Serum ADA, HbA1c, fasting and postprandial blood glucose and uric acid levels were measured.
In our study, fasting blood glucose [FBG], post prandial blood glucose [PPBG], HbA1c, ADA, uric acid were found to be increased in group B. In group C, FBG, PPBG, HbA1c, ADA were increased except uric acid level which is decreased compared to group B. A bell shaped curve was obtained when mean serum uric acid levels of all the three groups were observed.
A significant positive association was found between serum ADA and HbA1c in group B (r=0.405, p=0.006) and group C (r=0.465, p=0.001). A positive correlation was observed between uric acid and HbA1c in group B which was not statistically significant (r=0.199, p=0.189), whereas a significant negative correlation was observed between uric acid and HbA1c in group C (r= -0.3, p=0.046).
From the present case control study, it is concluded that there was an increase in serum Adenosine deaminase activity with increase in HbA1c. Raised serum uric acid was observed with moderately raised levels of HbA1c [<7%], but Uric acid levels lowered with further increases in HbA1c [>7%].