R. Bindu Madhavi1, H. N. Soumya2, D. Ravi Prakash3
To report the efficacy of topical Mitomycin-C in preventing local recurrences after incomplete surgical excision of ocular surface squamous neoplasia.
An interventional case report on a 70-year-old female patient with unilateral ocular surface squamous neoplasia (OSSN). Excision biopsy revealed invasive squamous cell carcinoma. All margins were positive for neoplastic cells. Patient was treated with topical Mitomycin-C 0.04% one drop, four times per day in alternate weeks for 4 weeks to prevent recurrences.
The patient was free of clinically detectable tumour & on impression cytology after a followup period of 10 weeks. Side effects included photophobia, mild redness & punctate epithelial keratopathy.
Postoperative topical Mitomycin-C application may be a useful adjunct to prevent recurrences in patients with incompletely excised OSSN.