Abstract

ROLE OF E-CADHERIN EXPRESSION IN THE PROGNOSIS OF BREAST CARCINOMA

Author(s): T. Sundari Devi

BACKGROUND Breast cancer is 2nd most common cancer in women after cervical cancer in India and is associated with high mortality and morbidity. Several parameters have been investigated to predict the prognosis in the breast cancer. E-cadherin, a calcium dependent epithelial cell adhesion molecule is a novel prognostic indicator. Its loss differentiates intralobular carcinoma from invasive duct cell carcinoma (IDCC) and its reduced expression has been associated with metastasis. The aim of the study is to assess the E-cadherin expression in breast cancer as a diagnostic marker in general and as a prognostic marker in metastasis of duct cell carcinoma. The aim of the study was to evaluate E-cadherin as a diagnostic marker, to differentiate between IDCC and ILC and as a novel prognostic marker with a potential to predict invasion and metastasis