Mohammed Ali Imtiaz 1 , Sushith 2 , Prathima M. B 3 , S. Reshma 4 , Madan Gopal R 5 , Francis N. P. Monteiro 6

ABSTRACT: BACKGROUND: Hypothyroidism may result in alteration in renal and muscular functioning resulting in renal failure and myopathies. This study adds to existing literature emphasizing the utility of periodic assessment of renal parameters and creatine kinase in hypothyroid patients. AIM: The aims of this study were to compare parameters of serum creatinine, creatinine clearance and serum creatine kinase in subclinical hypothyroid cases. MATERIALS AND METHODS: This case control study included twenty three diagnosed cases of subclinial hypothyroidism in the department of Endocrinology, Medicine and Surgery of A J Institute of Medical Sciences & Research Centre, Mangaluru, of age group 18-45 years. Results were compared with age and sex matched twenty five euthyroids. Serum T3, T4 and TSH; Serum creatinine; Creatinine clearance; and Serum creatine kinase were estimated and analysed. RESULTS: The results of the present study were obtained from 48 subjects out of whom 25 were controls and 22 were subclinical hypothyroids. Age distribution of study subjects shows that the mean age was 35.52±8.60 years for subclinical hypothyroids. Sex distribution of study subjects shows that majority of subclinical hypothyroid cases (81.8%) were females. Elevated levels of serum TSH with normal T3 & T4 was significant (p<0.001) in subclinical hypothyroid when compared to controls. Serum creatinine was elevated (p<0.05) with statistically significant decrease in creatinine clearance (p<0.001) in subclinical hypothyroids in comparison with controls. The serum creatine kinase was elevated (p<0.001) in subclinical hypothyroid patients. CONCLUSION: This shows that complications of hypothyroidism like acute renal failure, and myopathies can be prevented by monitoring thyroid hormones levels along with periodic assessment of renal parameters and creatine kinase in subclinical hypothyroid patients..