Reliability of Ultrasound in Patients with Chronic Liver Disease in the Diagnosis of Cirrhosis - A Systematic Review


Mishal Javaid*, Syed Muhammad Yousaf Farooq, Syeda Khadija Tul Sughra, Muhammad Zubair, Mehreen Fatima, Abeer Gohar and Lina Khaled Fares Jallad


Chronic liver disease is a major reason of morbidity and mortality. With a high prevalence of CLD, Ultrasonography can classify the appearances of cirrhosis and liver fibrosis etc.


The aim of this study was to assess the reliability of ultrasound in patients with chronic liver disease in the diagnosis of cirrhosis.


This systematic review and meta - analysis were carried out in agreement with the Preferred Reporting Items for Systematic Reviews and Meta -Analyses guidelines (PRISMA). We searched medicine and EMBASE research databases including Google scholar, PubMed, NCBI, Scopus, and Crossref databases from 2000 up to 2021. The keywords included were chronic liver disease, HCC and cirrhosis, hepatocellular carcinoma and ultrasound, liver cirrhosis, reliability of ultrasound in liver cirrhosis, cirrhotic liver, sonography of liver.


Our primary literature screening identified 242 articles. The variables such as accuracy, sensitivity, and specificity, positive predictive value and negative predicative value in patients with chronic liver disease were included of 53 studies 27,751 patients were included, out of which 1615 are male patients and 1011 are female patients in 17 studies (08 studies did not mentioned male to female ratio). The main causes of chronic liver diseases were included. Out of 53 studies, 18 studies included the causes of CLD. Out of total of 2235 patients, 781 patients had hepatitis B virus, 497 patients had hepatitis C virus, and 957 patients had cirrhosis.


With the several varieties of the causes, CLD is growing in incidence and cirrhosis is the most progressive phase of CLD. It is related with probable adverse event, such as the development of hepatocellular carcinoma which requires careful medical care. The ultrasonography parameters are helpful for providing predictive evidence and also for influential the best beneficial choices throughout follow - up of patients with CLD, mainly in patients with HBV or HCV in order to predict the incidence of HCC.