Abstract

RELEVANCE OF DUODENAL EOSINOPHILIA IN FUNCTIONAL DYSPEPSIA

Author(s): Premaletha Narayanan1, Anish Philip2, Asif Anchamparuthy Saifudhin3

BACKGROUND
Functional dyspepsia is a relatively common disorder in gastroenterology practice. Even though symptom criteria (like ROME III consensus criteria) have been proposed for the diagnosis of functional dyspepsia, it remains a diagnosis of exclusion due to a lack of a diagnostic test.
The aim of the study is to find the prevalence of significant duodenal eosinophilia in functional dyspepsia. Rome III consensus criteria were used to diagnose functional dyspepsia and mucosal biopsies were taken from gastric antrum, D1 and D2 by gastroduodenoscopy. Gastroduodenal eosinophil counts and presence of Helicobacter pylori (H. pylori) after special staining were assessed by pathologist.
MATERIALS AND METHODS
The underlying pathophysiology of functional dyspepsia has been poorly understood. It has been thought as a motility disorder of the stomach and abnormal gastric emptying, failure of fundic relaxation and gastric hypersensitivity has been documented in subsets of patients.
RESULTS
Out of the 84 patients studied, 23 patients (26.3%) had H. pylori in antral biopsy. 9 (9.47%) and 19 (20%) patients had eosinophil count above the cut-off values in D1 and D2, respectively. No significant association between gastric H. pylori infection and eosinophilia in D1 (p=1) and D2 (p=0.37).
CONCLUSION
Prevalence of duodenal eosinophilia in patients with functional dyspepsia was noted to be low in this study.