Author(s): Surya Prakasarao Salla1, Rithesh Patchipala2, Sailaja Paidi3
The aim of the study is to study the correlation of plasma 25-hydroxy vitamin D level with angiographic severity (Gensini score1) in Coronary Artery Disease (CAD). To determine the relation between vitamin D levels and angiographic severity of CAD2,3,4 using Gensini score using patients with normal angiographic findings as controls. After appropriate consent, following measurement of vitamin D levels with ECLIA method in all subjects, coronary angiogram was done. Experimental data suggest that vitamin D levels influences thrombotic deficiency5,6 and endothelial dysfunction,7 which plays an important role in CAD. The results of angiographic study and vitamin D were then analysed in a double-blinded fashion by a third party.
MATERIALS AND METHODS
Place of Study- Department of General Medicine and Cardiology of Andhra Medical College, Visakhapatnam, India.
Type of Study- Prospective study.
Period of Study- November 2015 to December 2016.
This study was approved by the ethical committee of Andhra Medical College, Visakhapatnam, Andhra Pradesh State.
Our final results showed a trend towards increasing severity of CAD and LV dysfunction with progressive decrease in vitamin D levels, but unfortunately were not statistically significant. However, in a few subsets like elderly patients and diabetics, the values were significant. Further studies should be contemplated to determine exact role of vitamin D in atherosclerotic heart disease.
Our study showed that there is a trend towards increasing severity of CAD with decreasing levels of vitamin D in various subsets of patients with atherosclerosis. However, the results were not statistically significant, but the encouraging trend in our study should pave path for further studies to determine the optimal role of vitamin D in the pathogenesis and prognostication of patients with CAD.
Serum Vitamin D Level, Angiographic Severity, Gensini Score, 25-Hydroxy Vitamin D Coronary Artery Disease