QTC INTERVAL CHANGES IN CLINICALLY HEALTHY SUBJECTS IN RELATION TO AGE AND SEX

Abstract

Shilpa N1, Veena H. C2, Vijaynath3

BACKGROUND AND OBJECTIVES: The diagnostic accuracy of ECG to differentiate between ‘Normal’ and ‘Abnormal’ rests entirely on analysis of distribution in ‘Normal’, i.e. clinically healthy, population. Age is biologically most important variable and there is significant age differences found in QTc interval measured. This study was undertaken to see the QTc changes in different age groups in healthy adults.

MATERIALS & METHODS: A study was conducted in a group consisting of 150 (75 male and 75 female) healthy adults in the age group 21 to 80 years. All the subjects were divided into different subgroups according to their sex and age. Lead II ECG was recorded on all subjects in supine position in an ambient temperature for 3 minutes by using Power lab 8/30 series with dual bio amplifier. And the analysis of the QTc interval was done by the software in the same instrument.

RESULTS: There was prolongation of QTc Interval with increasing age in both males and females.

CONCLUSION: In this study there were changes in QTc interval between males and females of different age groups. But all these changes were within physiological limits.

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