Protective Effect of Vitamin C and E on Enzymatic and Antioxidant System in Liver and Kidney Toxicity of Cadmium in Rats

Author(s): Venkataramanaiah Poli, Yenukolu Aparna, Renuka Madduru and Motireddy Srinivasulu Reddy*

Backgroud: The present study aimed to evaluate Heavy metals are persistent and uninterrupted ecological pollutants that are capable to cause numerous dysfunctions in target tissues of exposed animals as well as humans. Metallic components including Cadmium (Cd) arrive into the animal body then become stored mainly in the liver, kidney etc.

Methods: Despite the study of several years, no reports are available about actual medication for prolonged toxicity of heavy metals including Cd. Cd is one of the most common heavy metals that possess toxicological effects of numerous tissues of animal systems.

Result: In the present study an attempt was made to monitor the impact of Cd - toxicity in the tissues of wistar rats. BMR and TR potentials were found to be significantly (P < 0.05) inhibited, Tissue level oxidative metabolism represented by enzymes of Glycolytic and Kreb’s cycle enzymes were found to be significantly (P < 0.05) altered. Enzymes of glycolysis i.e. Phosphorylase ‘a’ and Aldolase were found to significantly elevated, whereas Kreb’s cycle and oxidative enzymes including SDH and Cytochrome-c-oxidase were found to be significantly inhibited, suggesting the metabolic shift from aerobiosis to anaerobiosis, visualized through increased lactate production at cellular level. Similarly antioxidant enzymes were also affected during Cd - toxicity, and stimulates the production of ROS, diminishing their structures, prohibition of the roles of antioxidants.

Conclusion: The findings from this study showed that a combination of Vitamin C and E enhances the biological recovery induced by Cd, pretreatment with antioxidants including Vitamin C and E decreases the oxidative stress, inhibits progressive fluctuations convinced through Cd, repaired the biochemical alterations and reverted to almost normal metabolic regimes. The addition of Vitamin C and E, to treat the detrimental effects caused due to Cd - toxicity, causing beneficial impacts including prevention and alleviation of Cd - toxicity. The individuals, who have high possibility of introduction to toxic metals should abundantly consume large quantities of fruits and vegetables on a regular basis, which are enriched with essential elements and vitamins. These nutritive complements have no side effects than chelation treatment as well as cost effective for individuals, who have unintentionally exposed to contamination of metal environs. So, nutrient supplements, which are enriched with natural antioxidants should be provided to overcome xenobiotic toxic stress.

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