Author(s): Rema Nair Sarkar1, Himaja Sayana2, Bhagyalakshmi Atla3
Breast cancer remains a global health problem with an increasing incidence. Proliferative breast diseases are recognised as one
of the risk factors in the development of carcinoma. This study was undertaken to know the frequency of proliferative lesions
and other lesions in association with breast carcinomas in mastectomy specimens.
MATERIALS AND METHODS
100 cases of excised carcinoma breast sent to the Department of Pathology for a three-year period at tertiary care centre was
thoroughly examined and changes adjacent to the tumour was recorded and tissue was subjected for histopathological
examination and results tabulated.
Infiltrating duct cell carcinoma, Not Otherwise Specified (NOS) type was present in 89% of cases. Among the associated lesions,
nonproliferative lesions constituted 16%, proliferative breast disease without atypia 29%, proliferative breast disease with atypia
10% and others 45%. Fibrocystic disease constituted 14% of cases, epithelial hyperplasia 15%, sclerosing adenosis 12% and
atypical ductal hyperplasia in 10% of cases. Other types of associated lesions were duct carcinoma in situ in 4 cases.
Proliferative lesions adjacent to carcinoma breast were seen in 39% of cases. Fibrocystic disease, epithelial hyperplasia,
sclerosing adenosis and atypical ductal hyperplasia being the commonest lesions adjacent to carcinoma breast in the present