Muralidharan Azhakesan1, John Christopher Ponnaian2, Indhuja Vaikundarajan3, Clemmency Baus4
To find the association between admission mean platelet volume in patients presenting with acute STEMI and mortality and to compare this index among diabetics and non-diabetics presenting with acute STEMI among patients admitted to Kanyakumari Government Medical College Hospital during the period January 2015 to December 2015.
A cross sectional study was carried out among 100 patients admitted to the ICCU with Acute Myocardial Infarction who underwent thrombolysis. Information about their glycaemic status, TIMI score, KILLIP class, Mean platelet Volume was collected.
Mean Platelet Volume was higher in diabetics compared to non-diabetics (9.94 fl for diabetics and 9.06 fl for non-diabetics). Patients who presented with higher TIMI score and KILLIP class had higher MPV values. Mortality was also higher for patients who presented with higher mean platelet volumes. Mortality was also higher for diabetics compared to non-diabetics (38% for diabetics and 8% for non-diabetics).
Diabetic patients presenting with MI had higher Mean Platelet Volume than non-diabetics confirming the hypothesis that platelets are large and hyperactive in diabetics. Higher mean platelet volume was associated with higher inpatient and one-month mortality indicating that it can be used as a prognostic marker in acute coronary events.