Abstract

Primary Biliary Cirrhosis- Autoimmune Hepatitis Overlap Syndrome

Author(s): Mohan Kumar Ravikumar1 , Sudagar Singh R. B.2 , Sivaprakash Varadan3 , Viswanathan Pandurangan4

Primary biliary cholangitis-autoimmune hepatitis overlap syndrome is a variant form of immunologically mediated hepatitis in which clinical and immunological features are suggestive of primary biliary cholangitis but histological evidence is in favour of autoimmune hepatitis. About 1% to 14% of patients with primary biliary cholangitis have evidence of autoimmune hepatitis. Primary biliary cholangitisautoimmune hepatitis overlap syndrome has to be differentiated from classical primary biliary cholangitis as treatment is different and greater progression of disease to cirrhosis is seen in overlap syndrome, thus requiring frequent monitoring of liver biochemical functions.Primary biliary cholangitis-autoimmune hepatitis overlap syndrome is a variant form of immunologically mediated hepatitis in which clinical and immunological features are suggestive of primary biliary cholangitis but histological evidence is in favour of autoimmune hepatitis. About 1% to 14% of patients with primary biliary cholangitis have evidence of autoimmune hepatitis. Primary biliary cholangitisautoimmune hepatitis overlap syndrome has to be differentiated from classical primary biliary cholangitis as treatment is different and greater progression of disease to cirrhosis is seen in overlap syndrome, thus requiring frequent monitoring of liver biochemical functions.