Predictors of Severity in Assessing Outcome in Leptospira Infection - An Observational Study

Author(s): Nabaruna Paul1 , Kallol Bhattacharjee2 , Sanjeeb Roy3 , P. Balamurali4

BACKGROUND Leptospirosis is a zoonotic disease caused by pathogenic Leptospira species. It may present with wide spectrum of clinical manifestations ranging from asymptomatic infection to fulminant disease that may prove fatal at times. The objectives of the study are to evaluate the clinical profile of leptospirosis patients and identify the predictors of severity in outcome in leptospira infection. METHODS A total of 50 patients seropositive for IgM leptospira admitted in a tertiary care hospital from 1st July 2017 to 31st December, 2018, were included in the study and evaluated for various clinical and laboratory parameters. RESULTS Out of 50 patients, majority of whom were male, the common symptomatology included fever followed by headache, myalgia, nausea and vomiting. The various complications that developed were acute kidney injury (AKI), meningitis, pneumonia, arrythmia, dyselectrolytemia etc. The total mortality observed was 10%. CONCLUSIONS Oliguric AKI, elderly subjects, sepsis and electrolyte disturbances may adversely affect the outcome in a patient with leptospirosis and thus is a pointer to the need for early intervention.