Observational Study of Serum Alanine Aminotransferase (ALT), Serum Aspartate Aminotransferase (AST) and Serum Alkaline Phosphatase (ALP) Levels in Type 2 Diabetic Patients

Author(s): Himanshu Jindal1 , Abhilasha Singh2 , Rajan Goyal3 , Abhishek Kamendu4

The relationship between liver enzymes like alanine aminotransferase (ALT), 
aspartate aminotransferase (AST), Alkaline phosphatase (ALP) and diabetes has
been studied, but the results of these are inconsistent. Several prospective studies 
have reported that ALT was associated with incident diabetes. We wanted to study 
the levels of serum alanine aminotransferase (ALT), serum aspartate 
aminotransferase (AST) and serum alkaline phosphatase (ALP) in patients of Type 
2 DM.
This is a hospital based observational study which was conducted in Narayan 
Medical College and Hospital, Jamuhar, Sasaram, Rohtas, Bihar. Alanine 
aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase 
(ALP), glycosylated haemoglobin (HbA1c), FBS, PPBS, total bilirubin, and hepatitis 
B surface antigen (HBsAg) were determined in all study participants.
The mean value was 96.35, 67.37, 152.78 and 1.098 for AST, ALT, ALP and total 
bilirubin. On multivariate analysis for effect of FBS, PPBS, HbA1c on the value of 
AST weak correlation was found with R square of 0.11. On the effect of FBS, PPBS, 
HbA1c on the value of ALT we found weak correlation with an R square of 0.079.
There is a weak correlation between deranged liver enzyme (AST, ALT and ALP) 
with HbA1c, FBS and PPBS. But still, liver functions should be monitored in diabetic