Padma Tejavath1 , Raju Bhukya2 , Raviraj Gudur Sharab3
BACKGROUND Post-Operative Nausea and Vomiting (PONV) are some of the most common postoperative complications in patients undergoing a surgical procedure under general anesthesia. The main objective of this study was to monitor the change in blood glucose concentration in patients undergoing surgery under general anesthesia and also to compare the efficacy of two different doses of dexamethasone on the prevention of PONV. METHODS A prospective randomized, double-blind comparative study has conducted at S.V.R.R.G.G.H, Tirupati, Andhra Pradesh, between December 2016 to November 2017 after obtaining permission from the institutional scientific and ethical committee among 90 patients of ASA grade 1 & 2, aged about 18 to 60 years, meeting inclusion and exclusion criteria. Informed consent was obtained from all patients. RESULTS Dexamethasone significantly reduced morbidity by decreasing PONV and postoperative pain during the first 24 hours of the postoperative period. The postoperative pain score was significantly lesser at 12 hours and 24 hours in the study group, and there was no significant difference in the pain scores at 0, 4, 8, 12 hours in both the study groups. CONCLUSIONS Injection dexamethasone significantly reduced morbidity by decreasing PONV and postoperative pain during the first 24 hours of the postoperative period with no significant rise in blood glucose levels. Also, better analgesia was noted compared to the placebo group.