Neelam Bharihoke1 , Vaibhavi Subhedar2 , Praveen Singh3 , Poonam Gupta4
BACKGROUND: Myocardial infarction is the major cause of morbidity and mortality in industrialized countries. Platelet activation is a hallmark of acute coronary syndrome. An increased MPV, an indicator of larger and more reactive platelets, has been associated with myocardial damage. AIM: to study platelet volume indices in Acute Myocardial Infarction (AMI), unstable angina (UA), stable coronary artery diseases (SCAD) and compare them with age and sex matched controls and to attempt a clinico-pathological correlation. SETTINGS AND DESIGN: This was a prospective hospital based stud, carried out on 286 patients. Patients were studied in three groups, IA, IB and II. Group IA comprised of patients with AMI, IB patients with stable coronary artery disease and group II was normal healthy controls. MATERIAL & METHODS: This is a comparative study of 286 subjects; 39 patients with AMI, 49 patients with SCAD and 198 were controls. MPV and other PVI were assessed by their venous samples. STATISTICAL ANALYSIS USED: Results were presented as mean, SD or frequency as appropriate. Other than these, two sample t test, one way ANOVA was used for statistical analysis of the data. For comparison of the three groups, ANOVA was used and for the comparison of two groups, t test was used. A p value of 0.05 was considered statistically significant. For the analysis of the data SPSS 20 was used. RESULTS: The mean platelet volume was significantly higher in patients with AMI (9.30+0.91) as compared to SCAD patients (8.38+0.85) and controls (7.71+1.05). CONCLUSION: Thus MPV is considered as a cost effective tool that may reflect an atherosclero-thrombotic tendency in human body.