Abstract

MACULAR GANGLION CELL COMPLEX (MGCC) THICKNESS CHANGES ANALYSIS IN MILD COGNITIVE IMPAIRMENT USING SPECTRAL DOMIAN OCT (SD-OCT), AS A NEWER BIOMARKER

Author(s): Vishrutha1, Viswanath B.N1, Shashidhar1, Ravi1, Sandhya1, Rashmi H G1, Nagarathna Magganur1, Pooja1

BACKGROUND
Mild cognitive impairment is a syndrome in which the patient will have subjective and objective memory deficit or have impairment of other cognitive function other than memory. The annual conversion rate from MCI to Alzheimer’s disease has been reported as 10 to 15 %.It is estimated that by 2020 , approximately 70% of the world population aged 60 and above will be living in developing countries with Dementia 14.2 % in India .Optical Coherence Tomography (OCT) is a non-invasive, non-contact imaging technique to analyze the thickness of macular ganglion cell complex thickness, decrease in thickness can correspond to neuronal death and loss of axons in macular ganglion cell complex.
METHODS
This is a non-randomized hospital based prospective cross-sectional study conducted at Minto Ophthalmic Hospital attached to BMCRI. Conducted from November 2019 to May 2021. This study was done 36 eyes of 35 patients. They were assessed by Mini Mental State Examination (MMSE) and spectral domain OCT done for the analysis of macular ganglion cell complex thickness changes.
RESULTS
It showed significant decrease in MGCC thickness in patients with mild cognitive impairment by SD OCT.
CONCLUSION
This concludes MGCC thickness analysis by SD - OCT is a newer tool in early detection of dementia or any other neurodegenerative conditions and helps in prevention of further progression to Alzheimer’s disease. Hence it is good to carryout OCT analysis in elderly people aged more than 60 to detect early neurodegenerative changes for early management.