Abstract

LANGERHANS CELL HISTIOCYTOSIS OF SMALL INTESTINE

Author(s): Parul Gupta, Anil Kumar Dhull, Vivek Kaushal

A 55-years old female patient with no known comorbidities presented with chief complaints of pain abdomen for 3- months associated with vomiting, abdominal lump and backache for past one month. Pain was insidious in onset, moderate intensity, originated in periumbilical and epigastric region and was relieved to some extent by oral analgesics. Abdominal lump developed in periumbilical region gradually increased in size upto the size of a tennis ball & was associated with abdominal distention and non-passage of stools & flatus. She was a chronic beedi smoker for 30-years. Contrast enhanced computerized tomography revealed an ill-defined growth in abdomen causing intestinal obstruction. She eventually got operated for sub-acute intestinal obstruction. She was a chronic beedi smoker for 30-years. On general physical examination patient was cachexic, ECOG status-3 and was taking liquid diet only. Local examination revealed tense and distended abdomen with unhealthy laparotomy scar gaping of 1.5×1.0 cm with granulation tissue in situ in periumbilical region. All haematological and biochemical investigations were within normal limits. are a subtype of histiocyte, which in turn refers to large white blood cells (WBCs) present in tissues. In general, the term ‘histiocyte’ also includes macrophages and dendritic cells. The World Health Organization classification of haematopoietic and lymphoid tumours classified disorders of histiocytes into three specific categories, namely dendritic cell disorders, macrophage-related disorders, and malignant histiocytic disorders. LCH falls under the first category of dendritic cell disorders