Author(s): Manish Ranjan Shrivastava, Deepak Kumar, Girindra Prasad Singh, Satyendra Kumar Pathak, Dinesh Sah, Ashok Kumar Chowdhar
Tuberculosis is an infectious disease which is prevalent worldwide, especially in developing nations and shows difficulty in elimination of disease due to resistant strains. So, there is a need of better and more effective control programs for tuberculosis patients and periodical survey for drug resistance patterns to formulate better treatment regimen and to make national tuberculosis program more strong and effective.
MATERIALS AND METHODS
A Prospective study has been conducted on 700 newly detected smear-positive TB patients who initiate receiving anti Tubercular drugs and had no history of previous anti tuberculosis treatment from April 2015 to April 2016. Sputum for AFB was done to detect the infection and Gene expert method and culture & sensitivity method done for detection of drug resistance of Isoniazid, Rifampicin, Ethambutol, Pyrazinamide & Streptomycin.
Out of 700 smear positive patients 628 patients were found culture positive and of them 560 were sensitive to all drugs, 48 patients shown resistance (7.8947%). Most common drug showing resistance is Rifampicin (3.94%) then Isoniazid (2.3%). Resistant pattern more for females, illiterate persons, married persons, rural patients with mean age 40.1 years, median age 38.5 years, S.D. 18.7, p-value 0.024112215.
CONCLUSIONIn our study more resistant pattern seen for Rifampicin, which is more in married, illiterates, rural, female patients. So, a periodical assessment of the prevalence of drug resistance pattern is very essential not only to know the effectiveness of the program but also to plan suitable regimens in areas of high prevalence.