Champa Koppad1 , Lakshmi K. S2
Occurrence of three consecutive pregnancy losses constitutes the classic definition of bad obstetric history (BOH). One of the important causes of BOH is the presence of antiphospholipid antibodies, which enhance the coagulability of blood in pregnancy. The association between phospholipid antibodies and recurrent miscarriage is called Antiphospholipid Syndrome (APS). Pregnant women with thrombotic APS have higher rates of pregnancy complications. APS is responsible for first trimester pregnancy loss in 90% of patients. APS is associated with events like thrombosis, vascular injury and vasoconstriction, all of which can abnormally reduce maternal-fetal interface blood flow. APS is best treated by a combination of LMWH and low-dose aspirin. Controlled clinical studies have demonstrated the superiority of heparin plus aspirin over aspirin alone in improving the birth rate.
