Parsa Mani Mekhala1, Lingam Aruna2, N. Ezhil Arasi 3, M. Swetha4, Perada Vasavi5
Breast cancer is a heterogeneous disease with variable morphological features, clinical outcomes and response to different therapeutic options. Gene expression profiling studies on breast carcinomas have revolutionised the classification of breast carcinomas into molecular subtypes enhancing the treatment protocols and offering better prediction of outcomes.
MATERIALS AND METHODS
The present study aims to discuss the special histological variants with special emphasis on their molecular phenotype using surrogate immunohistochemical markers.
Special variants of breast carcinomas diagnosed during the study period of two years from August 2013 and July 2015 were classified into molecular subtypes using immunohistochemical expression of ER, PR and HER-2.
Special types of breast carcinomas are very rare and have different clinicopathologic behaviours. It is important to know their characteristics to make proper management decisions and to predict the prognosis.