P. S. Usha Rani1, S. M. Saifullah Quraishi2, M. Manikanta3, P. Sudhakar4
Majority of patients with CKD stage V on maintenance hemodialysis have hyper homocysteinemia because of decreased excretion and loss of renal homocysteine metabolism. Homocysteine is a risk factor for vascular diseases. AIMS AND OBJECTIVES OF THE STUDY: To demonstrate hyper homocysteinemia in chronic kidney disease stage V on maintenance hemodialysis and to follow up these patients if they develop any vascular complications. MATERIALS AND METHODS: This study includes 30 patients with CKD stage V on maintenance hemodialysis with age variation between 35-72 years, and in these patients fasting plasma homocysteine levels was assayed. These patients were followed up for 2 years for vascular complications. CONCLUSION: Out of 30 patients of CKD stage V on maintenance hemodialysis, 25 patients (83.33%) have elevated homocysteine Levels. Majority of these patients, homocysteine levels are within moderate range (30-100μmol/l). On follow up no patient developed any major vascular complications such as symptomatic IHD, neurological deficits or any symptomatic peripheral vascular diseases.
