Abstract

HISTOPATHOLOGICAL CHANGES OF PLACENTA IN PRETERM PREGNANCY WITH SPECIAL REFERENCE TO INTRAUTERINE GROWTH RESTRICTION

Author(s): Prathibha S. D1, Anitha N2, Samikshya Ray3, Jayaprakash H. T4

BACKGROUND AND OBJECTIVES
The aim of this study was to analyse the placental lesions associated with restricted foetal growth in infants delivered for obstetric indications in preterm pregnancy with no apparent aetiologic factor.
MATERIALS AND METHODS
A prospective study was done in Pathology Department in collaboration with Department of Obstetrics and Gynaecology of Dr B R Ambedkar Medical College Hospital from July 2011 to June 2013 on pregnant women with Intrauterine Growth Restriction (IUGR) and preterm labour. Seventy cases from July 2011 to June 2013 were included in the study.
RESULTS
Of the 70 cases, 50 preterm and 20 term placentas studied, the weight of the placenta was less in IUGR compared to normal placenta. The incidence of IUGR is more in case of preterm placenta (94%) than term placenta (20%). Present study showed 50% of IUGR cases had increased intervillous space, 18% of preterm placenta had increased intervillous fibrin deposits, Acute chorioamnionitis in 24% cases of IUGR, chorangiosis in 18% cases of IUGR, infarction in 10% cases.
CONCLUSION
Pathological abnormalities are due to foetal and maternal vasculopathies in placenta.