Author(s): Jyothi Rani E. R., Anupama Raj Karattuthazhathu

BACKGROUND Being the most common cancer in female’s worldwide, breast cancer is the most important cause of cancer deaths. There are different subtypes of carcinoma breast. In this study, we have tried the surrogate classification of carcinoma breast based on Immunohistochemical profiling. We wanted to analyse the histomorphological features of carcinoma breast in all the modified radical mastectomy and TruCut biopsy specimens received in our department for a period of one year and classify the breast cancers according to the immunohistochemically markers- ER, PR, Her2neu. We also wanted to evaluate the association between the molecular subtypes and the Modified Scarf Bloom Richardson Grading System of carcinoma breast. METHODS This is a retrospective cross-sectional study, in which, we had included 256 confirmed cases of carcinoma breast, by histopathological examination. The H & E stained sections were studied using various parameters like, age, histological subtype, which were graded according to the Modified Scarf Bloom and Richardson grading system. The breast carcinoma cases were classified into 4 molecular subtypes according to ER, PR, and HER2/neu status. RESULTS According to our study, invasive ductal carcinoma was the most common subtype of breast cancer diagnosed in the institution. Of the three grades of carcinoma, Modified Bloom Richardson’s Grade 2 was most commonly seen. Surrogate classification based on IHC was done and showed the dominance of triple negative cancers in our study group. CONCLUSIONS Upon statistical analysis, there was significant association between the molecular classification and the histological grade.

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