Histomorphological Spectrum of Ovarian Tumours, 4 Years Experience in a Regional Institute

Author(s): Mutum Reeta Devi1 , Keerthivasan V.2 , Junali Tikhak3 , Badrinath V.4

BACKGROUND Worldwide, ovarian cancer is the sixth most common cancer in women and seventh most common cause of cancer death. For most western countries, ovarian cancer is the fifth most common cancer and ranks fourth in cancer mortality. For the western hemisphere it accounts for 4% of cancer in women and is the most frequent cause of death due to gynaecological cancer; whereas, in some European countries, and in parts of Eastern India, ovarian cancer is reported as the most frequent cause of death in women from gynaecological cancer. The present study was undertaken to analyse the histomorphological spectrum of ovarian tumours and their distribution in age groups in this region of the country. METHODS This combined retrospective and prospective study was carried out in the Department of Pathology, Regional Institute of Medical Sciences, Manipur for a period of 4 years i.e. from 1st January, 2016 to December, 2019. Representative tissues are processed routinely. Sections of tissue as well as sections from retrieved blocks are stain with Hematoxylin and Eosin stain. All slides are examined thoroughly. Tumours are classified according to WHO classification. RESULTS During the 4 years period, a total of 232 ovarian tumour specimens were received in the department. Out of these, 217 (93%) were benign, 3 (1.2%) were borderline and 12 cases (5.1%) were malignant. Surface epithelial tumours are the most common tumours encountered in the study. This is followed by germ cell tumours particularly mature cystic teratoma. Among the malignant tumours, granulosa cell tumour which is regarded as tumour with low malignant potential is the common one. Majority of tumours occurred in the age group of 31-40 years followed by 21-30 years and 41-50 years age groups. Youngest patient was 5 years old and oldest is 75 years old. Both are diagnosed as mature cystic teratoma. CONCLUSIONS Benign ovarian tumours are more common than the malignant tumours in all age groups. Serous cystadenoma is the most common tumour. Mature cystic teratoma is the 2nd most common tumour encountered. Thorough histopathological examination of any ovarian tumour is mandatory at any age.