Sudhamani C, Mini C. H, K. Chandramathy

BACKGROUND The study is conducted on patients of antepartum eclampsia to detect liver dysfunction and its effect on maternal outcome. MATERIALS AND METHODS This is a retrospective cross-sectional study conducted in the department of Obstetrics and Gynaecology of Government Medical College, Kozhikode for one year from June 2016 to May 2017. RESULTS There were 54 antepartum eclampsia patients. Among these, 70.4% were with liver dysfunction (group 1), and 29.6% were without liver dysfunction (group 2). Majority of the patients in both the groups belonged to gestational age between 32-37 weeks. The systolic and diastolic blood pressure were comparable between the groups. The mean platelet count and serum albumin levels were significantly low in group 1 patients. The mean SGOT, SGPT and LDH levels were significantly higher in group 1 patients. Maternal complications were seen only in patients of group 1 and mainly were abruptio placentae, postpartum haemorrhage (PPH), pulmonary oedema and acute renal failure. Platelet value improved within 24 hours in 44.7% of group 1 patients. SGOT, SGPT, LDH and serum albumin took longer time to recover. CONCLUSION Antepartum eclampsia is a leading cause of high maternal morbidity and mortality which may be attributed to the late detection, referral and delay in timely management of pre-eclampsia. A multidisciplinary approach involving the medical and para-medical staff, proper patient information and intervention will improve both maternal and foetal outcome.