Abstract

GANGLION CELL COMPLEX (GCC) THICKNESS ANALYSIS BY SPECTRAL DOMAIN OPTICAL COHERENCE (SD-OCT) IN GLAUCOMA SUSPECTS IN THE EARLY PREDICTION OF GLAUCOMA

Author(s): Rashmi HG1, Sujatha Rathod1, Shashidhar S1, Ravi B1, Nagarathna Magga1, Sandhya BH1

BACKGROUND
Glaucoma is irreversible, chronic, progressive optic neuropathy leads to characteristic visual field loss1. Studies have shown that, structural changes of glaucoma primarily affect Retinal Ganglion Cells (RGC) and their axons. Studies have found that, 15%-50% of glaucoma patients who were started on antiglaucoma medications, did not meet the criteria of Glaucoma. Glaucoma Suspect is defined as a person who has one of the following in at least one eye: like Optic nerve or nerve fibre layer defect suggestive of glaucoma, visual field abnormality consistent with glaucoma, IOP (Intra Ocular Pressure) consistently more than 21mmhg, diffuse or focal narrowing of disc rim and disc haemorrhage.
Optical Coherence Tomography (OCT) is a non-invasive imaging system gives high-resolution cross-sectional images of layers of retina.
METHODS
Hospital based Descriptive Cross-sectional study done for 1year period in Minto Ophthalmic Hospital attached to BMCRI. Macular Ganglion cell complex thickness analysed by Spectral domain optical coherence tomography. After obtaining approval and clearance from the institutional ethical committee, the patients fulfilling the inclusion criteria will be enrolled for the study after obtaining written informed consent and their Socio-demographic data (age, gender, address, occupation).Study will be done as per study design.
RESULTS
The study included 140 eyes 70 patients. It showed significant decrease in the macular GCC thickness in glaucoma suspects. Total GCC thickness of Right eye has decreased in 23 % of glaucoma suspects, and normal in 77 % of glaucoma suspects. Total GCC thickness has reduced in 26 % of glaucoma suspects, and normal in 74 % of glaucoma suspects.
CONCLUSION
MGCC thickness measurements may be good alternative or complentary measurements to peripapillary RNFL thickness and visual field test in the clinical evaluation and management of glaucoma.