Sherin Stephen1, Ryhanath C. C2
INTRODUCTION
Gamma Glutamyl Transferase is a protein found in high levels in the epithelial cells lining the bile ducts of liver. The manifestations of acute viral hepatitis is similar regardless of etiologic agent, but has important differences in terms of virology, epidemiology and chronic sequelae. Most cases of acute HCV infections are asymptomatic and the severity of liver image do not correlate with either the level of enzyme elevations or the amount of serum HCV virus RNA. The aim of the study is to establish GGT as a biochemical marker in viral hepatitis C. The specific objectives are to find out comparison and correlation of liver parameters used in the study. The present study group comprises 50 numbers each of patients and controls. Serum GGT, bilirubin total and direct, SGPT, SGOT, ALP, total protein, albumin, globulin and A/G ratio were investigated. The mean level of GGT was 111.04±19.48 IU/L inpatients and 27.8±1.2 IU/L in controls which was statistically significant. The liver enzyme levels, AST, ALT, and ALP were significantly elevated. A positive correlation of GGT level with ALP was observed in the study but not with ALT, AST or bilirubin levels. The serum GGT level were found to be elevated in the patients under study and was statistically significant. So GGT level can be used as a biochemical marker in hepatitis C infection.
