EFFICACY OF TOPICAL KETOCONAZOLE IN MANAGEMENT OF OTOMYCOSIS AND ITS OUTCOME A CLINICAL STUDY OF 100 CASES

Abstract

J. Bhupender Singh Rathod1, K. Samson Deva Kumar2, Ahmed Abdul Khabeer3, Ch. Bhanu Prathap Chander4, I. Phani Bhushan5, Thaduri Abhinav6, V. Dipin Kumar7, A. V. S. Hanumantha Rao

BACKGROUND
Otomycosis
OM is one of the common conditions encountered in a general otolaryngology clinic. The disease process is a
challenging and frustrating entity for both patients and otolaryngologists for it requires long term treatment and recurrence rate
remains. Otomycosis is called as otitis externa mycotica or mycotic external otitis . Otomycosis is the inflammation of the e xternal
a uditory c anal caused by the invasion of the fungus sometimes affecting middle ear. The f ungus grows and affixes on the top
most layers of the skin and the exotoxin produced by it acts as an irritant. As the fungus grows the superficial layers of the
epithelial cell are cast off and fill the external auditory canal with a mass of epithelial d ebris which looks like a wet blotting
paper or wet bread. It occurs because the protective lipid/acid balance of the ear is lost.
The aim of the study is to
assess, treat and follow up of otomycosis patients. In this study an effort is made to describe the
efficacy of Ketoconazole KC 2% ( o intment) local application when used in otomycosis patients after aural toilet.
MATERIAL AND METHODS
A total of 100 outpatients were studied during a period of 2 years from Sept
ember 20 11 to Aug ust 2013 in Gandhi Medical
College/Hospital.
RESULTS
Otomycosis comprised 2.4% of all new OPD cases. Of all the ear cases
otomycosis was seen in 5.3% of cases. Infection of
Aspergillus niger is more common followed by Aspergillus fumigatus and C andida albicans. Otomycosis is rarely associated with
other diseases. Response of patients to local application of k etoconazole was good with no side effects. 60% of patients
responded within 1 week and 40% more than one week.
CONCLUSION
Response to
ketoconazole local application does not change with age, side of the ear and male or female gender. Candida
albicans and Aspergillus fumigatus respond faster than Aspergillus niger.

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