Author(s): K. K. Mubarak1, Suhail Ummer2
Rocuronium bromide is a non-depolarising neuromuscular blocking drug commonly used in modern anaesthetic practice to facilitate endotracheal intubation and provide skeletal muscle relaxation. Pain on intravenous administration is an undesirable side effect of this drug. This study compares the effect of pretreatment with intravenous Thiopentone sodium 50 mg versus Lignocaine hydrochloride 40 mg in reducing this pain.
Double blind randomised control study conducted at the department of Anaesthesiology of a tertiary care teaching hospital.
MATERIALS AND METHODS
110 patients of age 16-60 years of American Society of Anaesthesiologists (ASA) physical status grade I and II of either sex for elective surgery under general anaesthesia were randomly divided into two groups using random number table. Group L received 40 mg of 2% lignocaine hydrochloride and Group T 50 mg of 2.5% thiopentone sodium intravenously before the administration of one tenth of the intubating dose of rocuronium bromide. Patients were asked to report the severity of pain on a Numerical Pain Rating Scale.
Mean age group in the study was 40.2 in Group L and 40.17 in Group T with female dominance of 78.5% and 87% in either group respectively. Mean body weight was 61.86 Kg in Group L and 60.19 Kg in Group T. 54.5% in the study population belonged to ASA physical status I and 45.5% were of ASA physical status II with no significant difference between the groups. There was statistically significant difference in the pain score between the two groups with 15.4% reduction in pain score with Group L compared to Group T.
From this study it is concluded that pretreatment with intravenous 40 mg of 2% lignocaine hydrochloride is more effective than 50 mg of 2.5% thiopentone sodium in reducing the pain due to intravenous administration of rocuronium bromide.