Abstract

DISTRIBUTION OF OCULAR PERFUSION PRESSURE IN HYPERTENSIVE PATIENTS AND ITS RELATIONSHIP IN DEVELOPMENT OF OPEN ANGLE GLAUCOMA

Author(s): Thangerani Raajaseharan1, Mythili Rajasekaran2

AIM
To study the distribution of ocular perfusion pressure in hypertensive patients and its relationship in development of open-angle glaucoma.
DESIGN
Cross-sectional observational study.
MATERIALS AND METHODS
A total of 200 subjects who were above 40 years of age diagnosed with essential hypertension by a physician were selected irrespective of their treatment status. Intraocular pressure was measured with Goldman applanation tonometry. Systolic and diastolic blood pressure were recorded with sphygmomanometer. Optic disc evaluation was done using +90D lens. Mean Ocular Perfusion Pressure (MOPP) was calculated using the standardised formula: [Mean Ocular Perfusion Pressure (MOPP) = 2/3 (Mean Arterial Pressure)- IOP] where Mean Arterial Pressure (MAP) = diastolic BP (DBP) + 1/3 systolic BP-diastolic BP (SBP-DBP). The difference between systolic and diastolic blood pressure is identified as the pulse pressure.
ANALYSIS
The association between MOPP and open angle glaucoma was analysed using Odds ratio in which the risk was higher in lowest quartile (Q1) [OR-1.9200] than in higher quartile (Q4) [OR-1.00].
CONCLUSION
Subjects with low ocular perfusion pressure due to increased IOP (or) decreased BP are more likely to develop open angle glaucoma providing further evidence in vascular pathogenesis.