P. K. Dash1

BACKGROUND: Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) used to treat mild-to-moderate pain, and helps to relieve symptoms of arthritis (e.g., osteoarthritis or rheumatoid arthritis), such as inflammation, swelling, stiffness, and joint pain.

OBJECTIVES: The purpose of this prospective study is to determine role of - Diclofenac in dermatological complications.

METHODS: In this descriptive, prospective, observational, cross sectional study, all patients who presented to the department of dermatology during this study period of 12 months from January 2011 - December 2012 in Farrukhabad were included.

RESULTS: Total number of males in the present study was 32(64%), females in the study was 18 (36%). Mean age was 35.28±6.4 (SD) years, youngest patient being 17 years old and oldest patient being 53 yrs old. Number of patients in the age group 10-20 years was 3(06%), 21-30 years was 11 (22%), 31-40 years was 23(46%), number of patients in 41-50 years was 7 (14%), number of patients in the age group 51-60 years was 06(12%), and number of patients in the age group 31- 50 years was 30(60%). Maximum number of patients was in their middle age between 31-50 years. Flushing was seen in 6(18.7%) patients in males, Urticarial rashes were seen in 12(37.5%) male, hypersensitivity was seen in 3(9.3%) males and ANA positivity was seen in 4(12.5%) males, itching was seen in 7(21.8%) male patients. Flushing was seen in 2(11.11%) patients in females, Urticarial rashes were seen in 6(33.33%) females, hypersensitivity was seen in 7 (38.88%) females and ANA positivity was seen in 1(5.55%) patient & itching was seen in 2(11.11%) male patients. P value of itching, Hypersensitivity and ANA positivity were significant.

CONCLUSION: There is significant percentage of patients who report with dermatological manifestations with Diclofenac as an anti-inflammatory and analgesic.