Author(s): Daruka K. M1
INTRODUCTION: Obesity is defined as abnormal or excessive fat accumulation that may impair health. Insulin resistance (IR) is associated with obesity, metabolic syndrome (MS), type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD) in adults and in the elderly. Waist–hip ratio (WHR) was suggested as a measure of body fat distribution and HOMA IR as a measure of insulin resistance. In this study, we assessed the body fat index and insulin resistance across normal, overweight and obese individuals. Methods: In this cross sectional study, we evaluated, height, weight, waist circumference, hip circumference, body mass index, waist to hip ratio, fasting blood glucose, fasting insulin and HOMA insulin resistance in healthy subjects attending routine health checkup in our college during. Subjects were excluded if they have any clinical, biochemical or diagnostic abnormalities.
RESULTS: A total of 71 subjects were studied, there were 21 normal, 24 overweight and 26 obese subjects. They were age and gender matched. We observed an increasing trend in WHR across increasing BMI. However it was not statistically significant. We also observed that HOMA IR is significantly more in obese than in both overweight and normal individuals. WHR correlated best with IR in obese.
CONCLUSION: We observed that HOMA IR is significantly more in obese than in both overweight and normal individuals. WHR correlated best with IR in obese.