Navneet Agrawal1, Nivedita Singh2
BACKGROUND
Though, there are experimental and clinical evidences on oxidant-antioxidant disturbance in obese patients, data supporting the same in centrally and peripherally obese subjects is lacking.
The aim of the study is to study the effect of body fat distribution on oxidative stress parameters in obesity.
MATERIALS AND METHODS
A prospective randomised study was done on 300 obese subjects and compared with 100 normal subjects having BMI between 19 to 25 kg/m2 in the Department of Medicine and Department of Biochemistry, G. R. Medical College, Gwalior. Patients were grouped as case (n=300) and control (n=100). Detailed physical examination and laboratory investigation including Fasting Blood Glucose (FBG) and complete lipid profile was done and recorded for each subject. The waist and hip was measured with inch tape to calculate the waist/hip ratio. Patients were divided on the basis of central and peripheral obesity. Superoxide Dismutase (SOD) activity and plasma Malondialdehyde (MDA) level were also estimated.
RESULTS
Mean age in case and control group was 46.2 ± 2.4 years and 44.5 ± 2.2 years (p>0.05) respectively with male predominance. Majority of subjects were centrally obese (82.33%) in centrally obese patients MDA levels (4.89 ± 1.26 vs. 4.06 ± 1.12 μmol/mL) were higher and SOD levels (8.62 ± 2.23 vs. 9.58 ± 1.26 units/mL) were lower compared to peripheral obesity (p<0.001). Significant (P<0.001) difference was observed for MDA level between case and control in centrally obese (4.89 ± 1.26 vs. 2.06 ± 0.76, respectively) and peripherally obese (4.06 ± 1.12 vs. 2.06 ± 0.76, respectively) subjects. Similarly, SOD level between case and control among centrally obese (8.62 ± 2.23 vs. 12.42 ± 2.18) and peripherally obese (9.58 ± 1.26 vs. 12.42 ± 2.18) subjects was significantly different (P<0.001).
CONCLUSION
The central fat deposition in abdomen or the apple-shaped obesity is associated with higher oxidative stress in obese subjects.
KEYWORDS
Oxidative Stress, Malondialdehyde, SOD, Obesity.
