Priyanka Jain1, Santosh Jajodia2, Lopamudra Bhuyan3, Jyoti Sheoran4, Garima Sarawgi5
Slowly progressive auto-degenerative neuropathy and changes of the optic nerve are well known in Open angle glaucoma. Glycaemic conditions in the body importantly may effect these damages, mutually or independent of the associated ocular pathology. An objective parameter if established for determining the correlation of the both would assist to set up proper ways of diagnosis and management of patients with Diabetics with POAG.
The aim of this study is to evaluate the optic nerve head (ONH) parameters of primary open-angle glaucoma (POAG) patients with and without diabetes and to investigate the effect of the metabolic control of diabetes on ONH topography.
MATERIALS AND METHODS
A study group of 61 eyes of 61 POAG patients with type 2 diabetes mellitus and a control group of 61 eyes of 61 POAG patients without diabetes were recruited for the study. Complete ophthalmic examinations of all patients were performed and the quantitative optic disc parameters were evaluated with HbA1c measurements of diabetic patients.
Mean RNFL thickness of the study group was statistically lower than the control group (P<0.001). The difference in other parameters of the OCT between the groups were insignificant. In the study group, the duration of the diabetes and HbA1c were not significantly correlated to any of the OCT parameters of ONH.
The duration of diabetes and HbA1c levels in diabetic population do not seem to show any significant correlation with the optic nerve head parameters and retinal nerve fibre thickness as measured with optical coherence tomography. However, larger and controlled studies are warranted to confirm these findings.