Ravish1, Mohan Kumar R2, Bindumathi P. L3
Current studies indicate that the pro-inflammatory action of Fibrinogen or the activation of inflammatory sensitive proteins predicts to the increased risk of pre-diabetes. Thus objective of the project was to be evaluate plasma levels of Fibrinogen, Total Antioxidant Capacity (TAC) and Body Mass Index (BMI) in pre-diabetes and to compare these with the normal men.
A prospective case control project was conducted, the subjects were divided into the following two groups. Group A: 34 male patients with pre-diabetes, Group B: 34 male, healthy individuals. Serum TAC and BMI were evaluated and BMI was calculated in both cases and controls. The results obtained were expressed as Mean±SD and was compared by using student ‘t’ test. Correlation was found between BMI, TAC and Fibrinogen. The mean age and SD of controls and cases were 54.67±11.74 and 51.12± 11.47 years respectively. Mean and SD of serum Total antioxidant capacity and Fibrinogen levels for controls and cases as 263.313±51.35 and 377.27±79.79 respectively mg/dl and respectively in controls and cases. TAC levels for controls and cases as 187.76±40.40 and 89.97±38.11 respectively mg/dl and respectively in controls and cases.
BMI was calculated and found to be 22.07±2.25 in controls and 29.20±3.55 in cases and were statistically significantly (p<0.001) altered in predicting severity of pre-diabetes. These data indicate that evaluation of Plasma Fibrinogen, BMI and TAC levels might predisposing the process of subclinical inflammation predisposing in the increased risk insulin resistance and thereby of pre-diabetes.
